In a major scientific advance, the latest version of our AI system AlphaFold has been recognised as a solution to this grand challenge by the organisers of the biennial Critical Assessment of protein Structure Prediction ( CASP ). Figuring out what shapes proteins fold into is known as the “protein folding problem”, and has stood as a grand challenge in biology for the past 50 years. They are large complex molecules, made up of chains of amino acids, and what a protein does largely depends on its unique 3D structure. Proteins are essential to life, supporting practically all its functions. In July 2022, we released AlphaFold protein structure predictions for nearly all catalogued proteins known to science.
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